Molecular Mechanisms of Atherogenesis and Restenosis : Possible Roles of Oxidized LDL and Oxidized LDL Receptors
نویسندگان
چکیده
منابع مشابه
The Dynamics of Oxidized LDL during Atherogenesis
Accumulating evidence indicates that oxidized low-density lipoprotein (OxLDL) is a useful marker for cardiovascular disease. The uptake of OxLDL by scavenger receptors leads to the accumulation of cholesterol within the foam cells of atherosclerotic lesions. OxLDL has many stimulatory effects on vascular cells, and the presence of OxLDL in circulating blood has been established. According to th...
متن کاملOxidized LDL, a critical factor in atherogenesis.
There is a great deal of experimental, epidemiological, and clinical evidence suggesting that disorders of lipid metabolism play an important role in the pathogenesis of atherosclerosis. To date, there have been many studies investigating the mechanisms by which high levels of LDL-cholesterol affect biology of vessels and cause atherosclerotic lesion formation [1,2]. It has become abundantly cl...
متن کاملDifferential Trafficking of Oxidized LDL and Oxidized LDL Immune Complexes in Macrophages: Impact on Oxidative Stress
BACKGROUND Oxidized low-density lipoproteins (oxLDL) and oxLDL-containing immune complexes (oxLDL-IC) contribute to formation of lipid-laden macrophages (foam cells). It has been shown that oxLDL-IC are considerably more efficient than oxLDL in induction of foam cell formation, inflammatory cytokines secretion, and cell survival promotion. Whereas oxLDL is taken up by several scavenger receptor...
متن کاملMinimally oxidized LDL offsets the apoptotic effects of extensively oxidized LDL and free cholesterol in macrophages.
OBJECTIVE Lipid-loaded macrophage-derived foam cells populate atherosclerotic lesions and produce many pro-inflammatory and plaque-destabilizing factors. An excessive accumulation of extensively oxidized low-density lipoprotein (OxLDL) or free cholesterol (FC), both of which are believed to be major lipid components of macrophages in advanced lesions, rapidly induces apoptosis in macrophages. I...
متن کاملLectin-like oxidized LDL receptor-1: Its diverse roles beyond an oxidized LDL receptor and clinical relevance
Oxidative stress induced by reactive oxygen species (ROS) plays an important role in the pathogenesis of various cardiovascular diseases. The redox state is determined by the balance between the pro-oxidative and anti-oxidative systems, and its imbalance leads to oxidative stress. ROS directly induces endothelial injury and inactivates endotheliumderived nitric oxide, which is a potent protecti...
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ژورنال
عنوان ژورنال: Japanese Journal of Neurosurgery
سال: 2003
ISSN: 0917-950X,2187-3100
DOI: 10.7887/jcns.12.355